Broadcaster: Channel 4
This 3.2 minute clip from Channel 4 looks at the use of organoids. Scientists at the Wellcome Trust Sanger Institute have, for the first time, grown tumours from 20 different colon cancer patients using matrigel to encourage the cells to form 3D “miniorgans” rather than growing in a monolayer as is more typical for cultured cells. Each organoid is different, reflecting the genetic errors in the donor, effectively a copy of the individual patients cancer grown in the lab. As a result a collection of tissues suitable for screening of existing and new drugs have been generated which may help both to select the most suitable drug for a given patient but also to improve our understanding of the cancers.