Broadcaster: BBC Radio 4
Genre: Radio magazine
Review by Eunice Muruako
In this 4 minute clip from Inside Science, presenter Adam Rutherford interviews Professor Paul Sharpe from King’s College London about the use of stem cells to regrow damaged dentine. Sharpe and his team have used Tideglusib, a drug originally as a treatment for Alzheimer’s disease in order to regrow teeth.
Below a thin layer of enamel, there is a thicker layer of another material called dentine. Although enamel cannot be regrown, it is possible to stimulate immature stem cells to become dentine, offering a natural alternative to metal or porcelain fillings.
After the rotten area of the tooth has been drilled out, Sharpe and his team insert a swab impregnated with the drug Tideglusib into the hole. The drug stimulates the Wnt signalling pathway, activating more stem cells. So far the work has been done in mice. In doing so they are taking advantage of the fact that the drug has previously been put through extensive safety trials when being considered as a treatment for neurological diseases such as Alzheimer’s. Sharpe hopes this might speed the process to clinical trials for this novel dental application, though even then clinical trials are unlikely to start before 2018 at the earliest.
For further information see this press release from the King’s College website.