Broadcaster: BBC Radio 4
Genre: Panel discussion, Fire-side chat
In this special episode of the BBC radio programme All in the mind (28 mins), host Claudia Hammond discusses the basis of memory formation with three leading researchers Tim Bliss, Graham Collingridge and Richard Morris who have been major players in developing our understanding of memory.
Tim Bliss draws attention to Donald Hebb’s pivotal book The Organization of Behavior and the aphorism “Cells that fire together, wire together”. Graham Collingridge then introduces the notion of long-term potentiation (LTP) as the molecular basis of memory, and particularly the role played by NMDA receptors in learning and AMPA receptors in memory. Errors in the functioning of any of hundreds of proteins can have detrimental impact on memory. Under-activation of LTP can be a contributory factor to schizophrenia. Continue reading
Broadcaster: BBC Radio 4
Review by Emma Sterling
“Circadian rhythms are a biological version of a clock inside humans and all other animals, plants and quite possibly in almost every living cell…These rhythms are a response to the most predictable condition of life on earth, that is, dark at night and bright during the day.”
“Circadian rhythms are one of the best examples of how genes relate to behaviour.”
In this episode of his series In Our Time (41 minutes), Melvyn Bragg talks with Professors Russell Foster, Debra Skene and Steve Jones about circadian rhythms, what they are and how they affect behaviour in humans and other organisms.
The programme includes a brief explanation about the subcellular process involved in circadian rhythms. In humans this takes place in what is described as the ‘master pacemaker’, formally known as the suprachiasmatic nuclei (SCN). This is a group of 50,000 cells located in the hypothalamus that are essential for producing the rhythm. Approximately 12-14 genes and their protein products are involved in the molecular feedback loop with an oscillation of approximately 24 hrs. In some individuals these oscillations are slightly longer, in others slightly less. These differences can affect whether that person is a morning or evening person. Other factors that can affect these oscillations include polymorphisms in the genes that control this process, and external factors such as food, drink and caffeine but none of the aforementioned are as important as light. Continue reading
Formal and informal research into the effects of electrical stimuli on brain function are being conducted
Broadcaster: Sky News
This is a short package (4 mins) from the Sky News breakfast show Sunrise. A reporter visits Andrew Vladimirov, described as part of a growing British community of brain hackers. Vladimirov uses a variety of techniques in an attempt to stimulate his brain function. As he points, the methods are used as part of various therapeutic programmes; he is looking to use the same approaches to achieve personal enhancement.
A second interview is conducted with Camilla Nord from UCL. She carries out research into transcranial direct current stimulation (TDCS) as a potential treatment for depression. Although she believes there may be some truth to the claims regarding brain hacking, she does caution against “playing with electricity at home”. Neither commercial nor home-made kits are currently subject to any UK regulation.