The three part series is an excellent introduction to our developing understanding of cell biology
Series of three hour-long documentaries presented by geneticist Adam Rutherford.
1. The Hidden Kingdom http://bobnational.net/record/222439
The first episode starts with the revelations brought by early microscopy. Specifically, the observation of minute organisms by Antonia van Leeuwenhoek. It moves on to discuss the work of Robert Hooke in confirming the existence of microbes, and broadening interest into analysis of other cells. Robert Brown observed and named the nucleus within a cell (and also described the phenomenon we now call “Brownian motion”. Theodor Schwann and Matthias Schleiden made vital observations about the importance of cells as the building blocks of both animals and plants (though they were not alone in getting distracted by prevailing notions of spontaneous generation). Louis Pasteur’s invention of the swan neck flask was ultimately crucial in ruling out this theory. The programme moves on to Robert Remak’s observation of cell division, for which the data – and the credit – was stolen by his “friend” Rudolf Virchow.
2. The Chemistry of Life http://bobnational.net/record/222440
In episode two, Rutherford’s attention moves to the experiments which established that DNA is the molecule of inheritance. This is my favourite episode in the series. It sweeps across from the original identification of DNA by Friedrich Miescher in 1868, through the work of Theodore Boveri in visualising chromosomes, and onto Thomas Hunt Morgan’s experiments with Drosophila melanogaster looking at patterns of inheritance and the start of mapping genes within those chromosomes. It continues onto the more familiar molecular biology of Griffith & Avery, Wilkins & Franklin and Watson & Crick. It finishes with a certain “yuk” factor as Walter Gehring demonstrates mutant Drosophila covered with eyes as the result of homeobox gene mutations.
3. The Spark of Life http://bobnational.net/record/222441
In the final episode, Rutherford moves to thinking about synthetic biology (a topic he returns to in the Horizon episode Playing God). One of the first developments in this regards involved adapting bacteria to make biodiesel. He puts these developments in the context of wider evolutionary theory, that all life sprung from one single organism.
Example usage: For several years I have used The Chemistry of Life with first year students. In a double-lecture slot (the episode is an hour long) I have shown the programme in its entirety, providing this A4 sheet to help students with their note-taking. In the remaining time we’ve reviewed some of the key curriculum-relevant content, particular reiterating the experiments by Griffiths and Avery.
The “modular” coverage of key discoveries lends itself to the overall programme being divided into shorter clips for specific usage. Since the links above go in effect to existing clips (albeit the full episode), to make sub-clips you would need to follow the link to the “full programme”.
As an Open University co-production, it was previously necessary to buy the rights to use of this material, however it is now included under the terms of the Educational Recording Agency license.