Anyone for Gene Editing? (Panorama)

panoramageneediting1Broadcaster: BBC1

Year: 2016

Genre: Documentary

URL: http://bobnational.net/record/421686

In June 2016, BBC current affairs programme Panorama conducted a whistle-stop tour around potential applications of CRISPR, the emerging gene editing technology.

In Medicine’s Big Breakthrough… Editing Your Genes (30 mins), Fergus Walsh talks to a number of key players in the field. These include Jennifer Doudna, credited as one of the co-creators of CRISPR as an editing took, George Church who is looking to humanise pig organs to reduce the likelihood of rejection, and Fyodor Urnov (from Sangamo Biosciences) who is trying to use the technology to tackle diseases such as AIDS and haemophilia. Alison van Eenennaam discusses genetic approaches to making horn-less cattle (which, she argues, is more humane than the current methods for removing existing horns). Walsh also visits biohacking entrepreneur Josiah Zayner, and Kathy Niakan from the Crick Institute who has the UK’s first licence to use CRISPR with human embryos.

The video is good at raising ethical as well as scientific questions. I can see this episode either serving as a very nice introduction to the topic, which students could be asked to watch before a face-to-face teaching session, or alternatively one or more of the vignettes could be used as illustrative clip(s) within a lecture.

A transcript of the programme is available via this link.

transcript from programme

There are a several introductory videos about CRISPR on YouTube. These include one produced by The Royal Society, available via this link. It starts from quite a low level, and so is probably most applicable for a school audience. A second, longer, video produced by Kurzgesagt (German for “in a nutshell”) is available via this link.

Meeting the demand for meat

Year: 2016

Broadcaster: BBC 1

Genre: Documentary

URL: https://learningonscreen.ac.uk/ondemand/index.php/clip/86970

Full original programme URL: https://learningonscreen.ac.uk/ondemand/index.php/prog/0B9E458F?bcast=121120092

Review by June Adams

The current worldwide demand for meat is huge, and growing faster than production rates can keep up with. How will we stop our commercial supply of meat from running out?

One way that farmers have tried to tackle the beef shortage is by producing cows that give more meat.  Belgian blues are a type of cow that has been specially bred to have 20% more muscle than the average cow, equating to 900 more quarter pounders. They can be reared to weigh up to one tonne! However, the extreme looking breed is controversial and difficult to farm. Belgian blue cows are unable to give birth naturally, and the calves often suffer from joint and heart problems. Is there a way to increase meat production without overburdening livestock?

In this five minute clip from the series Tomorrow’s Food, Professor Mark Post has managed to grow a burger in a lab by extracting stem cells from a tiny piece of meat, which then multiplied for 8 weeks in an incubator to make new muscle tissue. It takes 30 billion cells to make a single burger. The process is faster and may require less energy than rearing a whole cow, but it produces a very small amount of meat that costs a lot; a lab-grown burger costs over $200,000. In order to reduce costs to make the process viable on the market, production would need to be scaled up drastically – Olympic swimming pool sized incubation tanks! With some work, hopefully lab-grown burgers will become cheap enough to be sold commercially in less than 10 years.

World’s first lab-grown burger is eaten in London (5th August 2013) http://www.bbc.co.uk/news/science-environment-23576143

Dissected: Getting under your skin

foot dissection2Broadcaster: BBC4

Year: 2016 (originally 2014)

Genre: Documentary

URLs:
Hand (episode 1) https://learningonscreen.ac.uk/ondemand/index.php/clip/95314
Foot (episode 2) https://learningonscreen.ac.uk/ondemand/index.php/clip/91909

Review by Eunice Muruako

In two hour-long episodes, presenter George McGavin (Glasgow University) delves beneath the skin to expose the anatomy of the human hand and foot. The series sheds light on the various functions of the hand and foot by identifying the muscles, tendons and ligaments responsible for movement, and how the human anatomy compares with that of other animals.

Episode 1: Hand The dissection of the donor arm begins in the forearm to expose the muscles which give power to the hand for gripping and the tendons which attach each muscle to the bones in the fingers. The surgeon demonstrates how the tendons motion in the hand by tugging on the tendons to cur the fingers. The structure of the hand can be changed with heavy use – the X-ray of a frequent rock climber shows that the cortical bone (the hard outer layer of the skeleton) is thicker than in a non-climber the tendons and pulleys are also thicker, this allows their hands to maintain a firmer grip. Continue reading

Antibiotics: Britain’s greatest invention?

fleming

Invention or discovery? The case is put that sufficient work needed to be done after Fleming’s observation that the Penicillium mould killed bacteria

Broadcaster: BBC2

Year: 2017

Genre: Factual

URL: https://learningonscreen.ac.uk/ondemand/index.php/clip/99491

This clips (8:50) involves former newsreader Angela Rippon putting the case for antibiotics to be the winner of a poll to identify Britain’s Greatest Invention. She has a vested interest in the choice, having been saved from TB as a child. All other inventions being considered (the jet engine, steam engine, fridge, television, mobile phone and concrete) pale into insignificance, she argues, as you cannot benefit from the other inventions suggested if you are dead. This argument may have prevailed, as antibiotics were declared the winner on the night.

In truth this is not a particularly great clip. The opening gambit that “antibiotics literally kill bacteria” is a simplification and the popular myths surrounding the role played by Alexander Fleming are trotted out. There are, however, two features that might make this worth sharing with students.

The first is the debate over whether antibiotics are a discovery or an invention. This is an example of a broader debate about whether natural products are “invented” (this was also at the heart, for example, of the tensions regarding the legitimacy of patenting human genes). Rippon suggests there was sufficient need to technological innovation for antibiotics to be an invention not a discovery. I would have to concur with this view, especially since the fluoroquinolones, my favourite family of “antibiotics”, are in fact entirely man-made. Continue reading

Bacteriophage therapy (BBC News)

marthacBroadcaster: BBC News (and BBC 1)

Year: 2017

Genre: News

URL: https://learningonscreen.ac.uk/ondemand/index.php/clip/99430

There has been growing concern about antibiotic resistance over recent years. One alternative is to use bacteriophage (phage), viruses that attack bacteria. The idea is not new, it was actively pursued in the former Soviet Union, but is now being investigated in a rigorous way in western countries.

In this 2.5 minute news story, Martha Clokie from the University of Leicester discusses the potential to use freeze-dried phage in place of antibiotics. The initial trials are due to take place with farm pigs.

For more on this story follow this link.

For other programmes on phage therapy follow this link.

Is interfering with genes ethical? (The Big Questions)

TBQ - Crispr

Front row, left to right: Keith Fox, Jackie Leach Scully, Tony Juniper, David King, Trevor Stammers, Rabbi Laura Janner-Klausner, Jonathan Montgomery, Silvia Camporesi, Virginia Bolton, Ruth Stirton and David Wood. Steve Storey is on the extreme right-hand side of the second row.

Broadcaster: BBC2

Year: 2017

Genre: Debate, Factual

URL: https://learningonscreen.ac.uk/ondemand/index.php/clip/99294

On 11th June 2017, the final episode of the BBC’s ethical debate series The Big Questions was given over to a full hour’s discussion on the theme “Is interfering with genes ethical?”

As readers may know, this is an important and timely discussion. The emergence of CRISPR gene editing technology over the past three years has, for the first time, made it feasible to alter genes in situ and raises the potential/spectre (delete as applicable) of genuinely designer babies.

An impressive cast of bioethicists had been assembled to lead the debate (see caption of photo, above). A number of interesting and relevant points were raised. Despite the longer allocation of time, however, there was still a frustrating lack of depth on the topic. The focus was allowed to drift far too wide, embracing cryogenic preservation at one end of the spectrum and GM crops at the other. A moving account of the treatment of Steven Storey with his own stem cells was also not really on topic.

A full transcript of the episode is available via this link

transcript from programme

For a list of older episodes of The Big Questions on bioethical themes see this link at our sister site Bioethicsbytes.

The making of Quorn (Tomorrow’s Food)

Broadcaster: BBC 1

Year: 2016

Genre: Documentary

URLs:
Part 1 – https://learningonscreen.ac.uk/ondemand/index.php/clip/86966 (3.32 mins)
Part 2 – https://learningonscreen.ac.uk/ondemand/index.php/clip/86968 (3:10 mins)

Original programme URL:  https://learningonscreen.ac.uk/ondemand/index.php/clip/95311 (60 mins)

Review by June Adams

Around one third of UK households already buy meat alternatives, and the market is still rising as meat becomes more expensive. Being a versatile, nutritional, and super efficient meat alternative, could Quorn be the food of the future?

In two short sections from the third episode of his series Tomorrow’s Food, comedian turned science presenter Dara Ó Briain walks us through the process.

Production of Quorn starts with a single speck of freeze-dried fungus (Fusarium venenatum), reawakened and grown in a sugar-nutrient solution. In less than a week, it will grow to fill two ten-storey towers with 45 thousand tonnes of mycoprotein. Producing Quorn is ten times more efficient than rearing animals for meat, and contains less than half the calories and fat of beef mince and 78 times less cholesterol.

Turning the raw protein into edible products means further processing to give it the flavour and texture of meat. Freezing changes texture from a dough-like consistency to fibrous, as the ice crystals create fibrous bundles. Ingredients mixed in with Quorn before it is frozen creates the different flavours, and recipes can be tailored to suit the tastes of different countries, making Quorn incredibly versatile.

This clip might be of interest to microbiology or food technology students.

Intervention at any cost? The Charlie Gard case

cgardBroadcaster: Channel 4

Genre: News

Length: 3:16 mins

URL: https://learningonscreen.ac.uk/ondemand/index.php/clip/95288

When an infant has an illness that will, in all probabilities, prove fatal their parents face an agonising choice. Do you follow all possible interventions, or do you reach a point where you recognise that it is in the best interests of the child to withdraw treatment?

This dilemma is brought into stark relief by Charlie Gard who, at the time of writing, is the subject of a High Court case at the Royal Courts of Justice. There are several aspects that make this case particularly tricky, and particularly interesting from a medical ethics standpoint.

Charlie was born in August 2016 with a rare mitochondrial DNA depletion syndrome. He is deaf and blind, it is tricky to know how much pain he is aware of at present. Doctors at Great Ormond Street Hospital want to move to a regime of palliative care only. A crowdfunding project has raised over a million pounds parents and his parents want to take Charlie to the USA where a doctor is willing to enrol him on a trial of nucleoside bypass therapy, an experimental treatment which has an extremely low probability of alleviating some of his symptoms. He will almost certainly still die.

The case shines a spotlight on different medical culture in the UK and the USA. In the UK doctors tend to take a more cautious approach whereas doctors in America are more willing to try experimental procedures if the patient (or in this case, their parents) want to try and have the money to do so.

For further coverage of the case see: The Guardian and ITV News and a later report from the BBC.

 

GM tomatoes and goats: breakthroughs and setbacks (Tomorrow’s Food)

Year: 2016

Broadcaster: BBC 1

Genre: Documentary

Length: 6:53 mins

URL: https://learningonscreen.ac.uk/ondemand/index.php/clip/86972

URL full original programme (60 mins):  https://learningonscreen.ac.uk/ondemand/index.php/prog/0B9E458F

Review by June Adams

At the John Innes Centre in Norwich, a genetically modified “supertomato” has been produced which could help make us all healthier. Using genes from snapdragons, Professor Cathie Martin has genetically modified tomatoes to produce anthocyanins, making them appear bright purple. Anthocyanins are pigment compounds naturally produced in many plants, and in our diets are thought to help reduce the risk of heart disease, stroke, and even cancer. Tomatoes were chosen to host these genes because they are the most consumed fruit in the word, are added as an ingredient to many other foods, and are accessible to people on a low income. Continue reading

A History of the Brain

radioBroadcaster: BBC Radio 4
Year: Originally broadcast 2011 (repeated periodically)
Genre: Radio, Documentary, History of Science
URLs: See below for each episode

Review by Eunice Muruako
Dr Geoff Bunn (Manchester Metropolitan University) presents a series of ten 15-minute programmes spanning 5000 years of cultural and scientific progress in understanding how the brain works.

Episode 1: A Hole in the Head (https://learningonscreen.ac.uk/ondemand/index.php/clip/90227)
The series begins with an introduction to one of the earliest forms of brain surgery, trepanation (3.00). Trepanation was the process by which a small piece of skull was cut away to relieve pressure believed to be caused by the build-up of fluid. Bunn explains that, even in the ancient world, connections were being made with how particular areas of the brain affected certain functions. We learn that Egyptian physician, Imhotep, understood that injury to one side of the brain could paralyse limbs on the opposite side (10.38).

Episode 2: The Blood of Gladiators
(https://learningonscreen.ac.uk/ondemand/index.php/clip/90228)
Various philosophers had conflicting ideas about the role of the brain and its connection to the location of the soul. Aristotle, for example, considered the heart to have primacy over the brain because it was centrally located and developed first in the embryo (9.09). Whereas Galen agreed with Hippocrates that the body was ruled by the brain (12.37). Ailments which were previously attributed to the gods could instead be understood in terms of natural causes affecting the brain. Continue reading